TNF-IP 8L2 rabbit pAb

Domain: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding. function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. similarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. subunit: May interact with CASP8; however, such result is unclear since PubMed: 19079267 could not reproduce the interaction with CASP8.

Product Specifications

Background

Domain:The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding., function:Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis., similarity:Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily., subunit:May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.

Product Name Alternative

TNFAIP8L2; Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; Inflammation factor protein 20

UniProt

Q6P589

Swiss Prot

Q6P589

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human TNFAIP8L2. AA range:11-60

Target

TNF-IP 8L2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

20kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

20kD

Fragment

IgG

Subcellular Location

Cytoplasm

Other Product Names

TNFAIP8L2; Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; Inflammation factor protein 20