CHSY2 rabbit pAb

Catalytic activity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl- (1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl- (1->3)-N-acetyl-beta-D-galactosaminyl- (1->4)-beta-D-glucuronosyl-proteoglycan. Catalytic activity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl- (1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl- (1->4)-beta-D-glucuronosyl- (1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan. Cofactor: Divalent cations. Highest activities are measured with manganese. Can also utilize cobalt. function: Has both beta-1, 3-glucuronic acid and beta-1, 4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. online information: GlycoGene database, PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family. subunit: Binds CHSY1. tissue specificity: Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, small intestine and placenta.