VDR (phospho Ser208) rabbit pAb
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011],
Product Specifications
Background
Synonyms
VDR; NR1I1; Vitamin D3 receptor; VDR; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Gene ID
7421
UniProt
P11473
Cellular Locus
Nucleus. Cytoplasm. Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3..
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IF, ELISA
Validated Applications
WB,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
50kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7494-1.pdf
Observed Molecular Weight
50 kD
Subcellular Location
Nucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331) . Localization to the nucleus is enhanced by vitamin D3. .
Other Product Names
VDR; NR1I1; Vitamin D3 receptor; VDR; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Gene ID (Human)
7421
SwissProt (Human)
P11473
Available Sizes
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