PJAK2 (1001-1013)

PJAK2 (1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2 (1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2 (1001-1013) can be used for the study of immune regulation and infection[1][2][3].

Product Specifications

CAS Number

[1259928-08-9]

UNSPSC

12352209

Target

IFNAR; Interleukin Related; JAK

Type

Peptides

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pjak2-1001-1013.html

Purity

99.89

Solubility

DMSO : 1.89 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N2[C@H](C(O)=O)CCC2)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H]3N(C([C@H](CC(C)C)N)=O)CCC3)=O)=O)=O)=O)=O)CC4=CC=C(OP(O)(O)=O)C=C4

Molecular Formula

C76H118N17O26P

Molecular Weight

1716.82

References & Citations

[1]Ahmed CM, et al. SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function. Front Immunol. 2015 Apr 21;6:183. |[2]Waiboci LW, et al. Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist. J Immunol. 2007 Apr 15;178 (8) :5058-68.|[3]Ahmed CM, et al. A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus. Front Immunol. 2015 Nov 11;6:574.