Stat2 (phospho Tyr631) rabbit pAb
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
Product Specifications
Background
Synonyms
STAT2; Signal transducer and activator of transcription 2; p113
Gene ID
6773
UniProt
P52630
Cellular Locus
Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT2 around the phosphorylation site of Tyr631. AA range:597-646
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, ELISA
Validated Applications
IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7295-1.pdf
Subcellular Location
Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .
Other Product Names
STAT2; Signal transducer and activator of transcription 2; p113
Gene ID (Human)
6773
SwissProt (Human)
P52630
Available Sizes
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