HDAC6-IN-35
HDAC6-IN-35 (compound C4 (ZINC000077541942) ) is a potent and BBB-penetrated HDAC6 inhibitor with the IC50 of 4.7 μM. HDAC6-IN-35 shows cell toxicity against MDA-MB-231 with EC50 of 40.6 μM[1].
Product Specifications
CAS Number
1394615-06-5
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-35.html
Solubility
10 mM in DMSO
Smiles
O=C1CC2(CN1)CCN(CC2)CC3=CC=CC(OCC4=CC=CC=C4Cl)=C3
Molecular Formula
C22H25ClN2O2
Molecular Weight
384.90
References & Citations
[1]Uba AI, et al. Discovery of novel inhibitors of histone deacetylase 6: Structure-based virtual screening, molecular dynamics simulation, enzyme inhibition and cell viability assays. Life Sci. 2024;338:122395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![H6PD Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2C12]](https://cdn.genprice.uk/products/937/68dd1b66061270361ea14703/imageurl/ta501213am.webp)
TA501213AM 100 µL
H6PD Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2C12]
Sign In for Pricing
View Details 