ABHD4 rabbit pAb
Caution: Thr-291 is present instead of the conserved His which is expected to be an active site residue. function: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. similarity: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
Product Specifications
Background
UniProt
Q8TB40
Swiss Prot
Q8TB40
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ABHD4. AA range:251-300
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane, lipid particle
Other Product Names
ABHD4; Abhydrolase domain-containing protein 4; Alpha/beta-hydrolase 4; Lyso-N-acylphosphatidylethanolamine lipase
Gene ID (Human)
63874
Available Sizes
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