Tip5 rabbit pAb

Function: May play a role in transcriptional regulation interacting with ISWI. May serve a specific role in maintaining or altering the chromatin structure of the rDNA locus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Belongs to the WAL family. similarity: Contains 1 bromo domain. similarity: Contains 1 DDT domain. similarity: Contains 1 MBD (methyl-CpG-binding) domain. similarity: Contains 1 PHD-type zinc finger. similarity: Contains 4 A. T hook DNA-binding domains. subcellular location: Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. subunit: Together with SMARCA5, it forms a complex termed NoRC (nucleolar remodeling complex). tissue specificity: Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.