RGS7 rabbit pAb

Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G (o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. PTM: Palmitoylated. PTM: Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. similarity: Contains 1 DEP domain. similarity: Contains 1 G protein gamma domain. similarity: Contains 1 RGS domain. subunit: Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP.

Product Specifications

Background

Function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G (o) -alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations., PTM:Palmitoylated., PTM:Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity., similarity:Contains 1 DEP domain., similarity:Contains 1 G protein gamma domain., similarity:Contains 1 RGS domain., subunit:Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity) . Interacts with 14-3-3 protein Tau and SNAP25BP.

Product Name Alternative

RGS7; Regulator of G-protein signaling 7; RGS7

UniProt

P49802

Swiss Prot

P49802

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human RGS7. AA range:155-204

Target

RGS7

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Buffer

-20°C/1 year

Molecular Weight

65kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

65kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytosol . Cytoplasm . Cell membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594) . Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264) . .