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O-Arachidonoyl glycidol

O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC50 value of 4.5 µM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC50s of 19, 12 µM, respectively[1].

Product Specifications

CAS Number

[439146-24-4]

UNSPSC

12352005

Hazard Statement

H225-H302-H319-H336

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/o-arachidonoyl-glycidol.html

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCC1CO1)=O

Molecular Formula

C23H36O3

Molecular Weight

360.53

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P330-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Cisneros JA, et al. Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4;50 (20) :5012-23.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-131995/O-Arachidonoyl-glycidol-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-131995/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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