CD45 (phospho Ser1007) rabbit pAb
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of Cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which enc
Product Specifications
Background
Synonyms
PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45
Gene ID
5788
UniProt
P08575
Cellular Locus
Cell membrane ; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CD45 around the phosphorylation site of Ser1007. AA range:981-1030
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IF, ELISA
Validated Applications
WB,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
150kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES6941-1.pdf
Observed Molecular Weight
150 kD
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts. .
Other Product Names
PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45
Gene ID (Human)
5788
SwissProt (Human)
P08575
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal GCHFR Antibody (GCHFR/7734) [Janelia Fluor 525]](https://cdn.genprice.uk/genprice/genprice2.png)
Mouse Monoclonal GCHFR Antibody (GCHFR/7734) [Janelia Fluor 525]
Sheep Leucine Rich Repeat Containing Protein 17 (LRRC17) ELISA Kit
Sheep Leucine Rich Repeat Containing Protein 17 (LRRC17) ELISA Kit
Sheep Leucine Rich Repeat Containing Protein 17 (LRRC17) ELISA Kit