PAF-R rabbit pAb
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Product Specifications
Background
Product Name Alternative
PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
UniProt
P25105
Swiss Prot
P25105
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243
Target
PAF-R
Clonality
Polyclonal
Source
Rabbit
Applications
IF; ELISA
Concentration
1 mg/ml
Dilution
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein .
Other Product Names
PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr
Gene ID (Human)
5724
Available Sizes
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