Nicalin rabbit pAb
Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. similarity: Belongs to the nicastrin family. subunit: Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
Product Specifications
Background
Synonyms
NCLN; Nicalin; Nicastrin-like protein
Gene ID
56926
UniProt
Q969V3
Cellular Locus
Endoplasmic reticulum membrane ; Single-pass membrane protein.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human NCLN. AA range:474-523
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
63kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES6862-1.pdf
Observed Molecular Weight
63 kD
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass membrane protein .
Other Product Names
NCLN; Nicalin; Nicastrin-like protein
Gene ID (Human)
56926
SwissProt (Human)
Q969V3
Available Sizes
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