A1Up rabbit pAb

PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 UBA domain. similarity: Contains 1 ubiquitin-like domain. subcellular location: May associate with the endoplasmic reticulum. subunit: Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. tissue specificity: Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

Product Specifications

Background

PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 UBA domain., similarity:Contains 1 ubiquitin-like domain., subcellular location:May associate with the endoplasmic reticulum., subunit:Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum., tissue specificity:Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

UniProt

Q9NRR5

Swiss Prot

Q9NRR5

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human UBQLN4. AA range:201-250

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

54kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

54kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Chromosome . Endoplasmic reticulum . Cytoplasm, perinuclear region . Cytoplasmic vesicle, autophagosome . Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365) . Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234) . In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738) . .

Other Product Names

UBQLN4; C1orf6; CIP75; UBIN; Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75