Formin 2 rabbit pAb

This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015],

Product Specifications

Background

This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47) . Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

UniProt

Q9NZ56

Swiss Prot

Q9NZ56

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human FMN2. AA range:1541-1590

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm, cytoskeleton . Cytoplasm, cytosol . Cytoplasm, perinuclear region . Nucleus . Nucleus, nucleolus . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cell cortex . Colocalizes with the actin cytoskeleton (PubMed:20082305) . Recruited to the membranes via its interaction with SPIRE1 (By similarity) . Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity) . Accumulates in the nucleus following DNA damage (PubMed:26287480) . .