PKR (phospho Thr446) rabbit pAb
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Product Specifications
Background
Product Name Alternative
UniProt
P19525
Swiss Prot
P19525
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446. AA range:413-462
Target
PKR
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
62kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
62kD
Fragment
IgG
Subcellular Location
Other Product Names
Gene ID (Human)
5610
Available Sizes
Frequently Asked Questions
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