β-1,4-GalNAc-T rabbit pAb

Catalytic activity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl- (1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl- (1->4)-beta-D-glucuronyl- (1->3)-beta-D-galactosylproteoglycan. function: Transfers 1, 4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. online information: Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase 1, online information: GlycoGene database, PTM: N-glycosylated. similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family. tissue specificity: Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

Product Specifications

Background

Catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl- (1->3) -D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl- (1->4) -beta-D-glucuronyl- (1->3) -beta-D-galactosylproteoglycan., function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA) . Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage., online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1, online information:GlycoGene database, PTM:N-glycosylated., similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family., tissue specificity:Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

UniProt

Q8TDX6

Swiss Prot

Q8TDX6

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human CSGALNACT1. AA range:201-250

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

60kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

60kD

Fragment

IgG

Subcellular Location

Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .

Other Product Names

CSGALNACT1; CHGN; GALNACT1; Chondroitin sulfate N-acetylgalactosaminyltransferase 1; CsGalNAcT-1; Chondroitin beta-1; 4-N-acetylgalactosaminyltransferase 1; Beta4GalNAcT-1