(RS) -4CPG
(RS) -4CPG ((RS) -4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS) -4CPG (500μM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6±1.7% (n = 8) in IP3R1 (-/-) mice and 116.9±1.8% (n = 5) in IP3R1 (+/+) mice.
Product Specifications
CAS Number
[7292-81-1]
Product Name Alternative
(RS) -4-Carboxyphenylglycine
UNSPSC
12352005
Hazard Statement
H302
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rs-4cpg.html
Purity
99.04
Smiles
O=C(O)C(N)C1=CC=C(C(O)=O)C=C1
Molecular Formula
C9H9NO4
Molecular Weight
195.17
Precautions
H302
References & Citations
[1]Neuronal plasticity in hippocampal mossy fiber-CA3 synapses of mice lacking the inositol-1,4,5-trisphosphate type 1 receptor
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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