AMPKα1 (phospho Ser496) rabbit pAb
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
5562
UniProt
Q13131
Cellular Locus
Cytoplasm. Nucleus. In response to stress, recruited by p53/TP53 to specific promoters..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Canine
Reactivity
Human; Mouse; Rat; Canine
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPK1 around the phosphorylation site of Ser496. AA range:451-500
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
62kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES6733-1.pdf
Observed Molecular Weight
62 kD
Subcellular Location
Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .
Other Product Names
Gene ID (Human)
5562
SwissProt (Human)
Q13131
Available Sizes
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