Sitneprotafib
Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model[1].
Product Specifications
CAS Number
[2245082-05-5]
Product Name Alternative
JAB-3312
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jab-3312.html
Purity
99.31
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N[C@H](C(C=CC=N1)=C1C2)C2(CC3)CCN3C(N=C4)=CN=C4SC5=C(Cl)C(N)=NC=C5
Molecular Formula
C21H22ClN7S
Molecular Weight
439.96
References & Citations
[1]Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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