PinX1 rabbit pAb

Domain: The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity. function: Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. similarity: Belongs to the PINX1 family. similarity: Contains 1 G-patch domain. subcellular location: In nucleoli and at telomere speckles. subunit: Binds to MCRS1, TERT and TERF1. tissue specificity: Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Product Specifications

Background

Domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity., function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor., similarity:Belongs to the PINX1 family., similarity:Contains 1 G-patch domain., subcellular location:In nucleoli and at telomere speckles., subunit:Binds to MCRS1, TERT and TERF1., tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

UniProt

Q96BK5

Swiss Prot

Q96BK5

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Nucleus . Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Other Product Names

PINX1; LPTL; LPTS; PIN2/TERF1-interacting telomerase inhibitor 1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1