N-Shc rabbit pAb
Function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. PTM: Tyrosine phosphorylated. similarity: Contains 1 PID domain. similarity: Contains 1 SH2 domain. subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. tissue specificity: Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.
Product Specifications
Background
Synonyms
Gene ID
53358
UniProt
Q92529
Cellular Locus
Cytosol,plasma membrane,
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human SHC3. AA range:291-340
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, ELISA
Validated Applications
IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
48kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES6607-1.pdf
Observed Molecular Weight
48 kD
Subcellular Location
Cytosol, plasma membrane
Other Product Names
Gene ID (Human)
53358
SwissProt (Human)
Q92529
Available Sizes
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