WWOX rabbit pAb

WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

Product Specifications

Background

UniProt

Q9NZC7

Swiss Prot

Q9NZC7

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

47kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

47kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . Mitochondrion . Golgi apparatus . Partially localizes to the mitochondria (PubMed:14695174) . Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity) . Translocates to the nucleus in response to TGFB1 (PubMed:19366691) . Isoform 5 and isoform 6 may localize in the nucleus. .