PDHK1 (phospho Tyr9) rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. similarity: Belongs to the protein kinase superfamily. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. similarity: Contains 1 PH domain. similarity: Contains 1 protein kinase domain. subcellular location: Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. subunit: Interacts with TUSC4. tissue specificity: Appears to be expressed ubiquitously.