Ar-V7-IN-1
Ar-V7-IN-1 is a potent inhibitor of Ar-V7. Ar-V7-IN-1 inhibits the transcriptional activity of androgen receptor (AR) and the secretion of prostate-specific antigen (PSA) with an eGFP IC50 of 1232 nM and the PSA IC50 of 1391 μM. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer[1].
Product Specifications
CAS Number
[2230880-25-6]
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-v7-in-1.html
Purity
98.02
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
BrC1=C(Br)N(C2=CSC(N3CCOCC3)=N2)C=N1
Molecular Formula
C10H10Br2N4OS
Molecular Weight
394.09
References & Citations
[1]Fuqiang Ban, et al. Ar-v7 inhibitors. Patent WO2018114781A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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