C-Myc (phospho Thr358) rabbit pAb
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
P01106
Swiss Prot
P01106
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr358. AA range:325-374
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; IP; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
50,(also ~60KD in some samples)
Storage Conditions
-20°C/1 year
Observed Molecular Weight
50, (also ~60KD in some samples)
Fragment
IgG
Subcellular Location
Nucleus, nucleoplasm . Nucleus, nucleolus .
Other Product Names
MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64
Gene ID (Human)
4609
Available Sizes
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