Formic acid (ammonium)

Formic acid ammonium is the ammonium salt form of formic acid, which is an endogenous metabolite. Formic acid ammonium activates the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling pathway in endothelial cells and inhibits calcium ion influx in vascular smooth muscle cells, resulting in vasomotor relaxation. Formic acid ammonium inhibits cytochrome C oxidase (CcO) and disrupts the electron transport chain, leading to ATP depletion. Formic acid ammonium can be used as a feed additive, which can lower the feed pH value, inhibit the growth of microorganisms (such as Escherichia coli, Salmonella), and extend the shelf life of the feed[1][2][3].

Product Specifications

CAS Number

[540-69-2]

Product Name Alternative

Ammonium formate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ATP Synthase; Bacterial; Calcium Channel; NO Synthase

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/formic-acid-ammonium-salt.html

Purity

98.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]C(O[NH4])=O

Molecular Formula

CH5NO2

Molecular Weight

63.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Eisemann JH, van Heugten E. Response of pigs to dietary inclusion of formic acid and ammonium formate. J Anim Sci. 2007 Jun;85 (6) :1530-9.|[2]Zhang Q, et al. Formic acid up-regulates vascular tension through nitric oxide-cGMP signaling pathway. Chem Biol Interact. 2019 Aug 25;309:108710. |[3]Kapur BM, Baber M. FASD: folic acid and formic acid - an unholy alliance in the alcohol abusing mother. Biochem Cell Biol. 2018 Apr;96 (2) :189-197.