MRE11 (phospho Ser264) rabbit pAb
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
Gene ID
4361
UniProt
P49959
Cellular Locus
Nucleus. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MRE11 around the phosphorylation site of Ser264. AA range:230-279
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA, IHC
Validated Applications
WB,ELISA,IHC
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Molecular Weight
80kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES6268-1.pdf
Observed Molecular Weight
80 kD
Subcellular Location
Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .
Other Product Names
Gene ID (Human)
4361
SwissProt (Human)
P49959
Available Sizes
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