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GARP&Latent TGF beta Complex, Mouse (HEK293, His)

GARP/latent TGF-b1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. GARP&Latent TGF beta Complex Protein, Mouse (HEK293, His) is a biotinylated recombinant protein (GARP (I18-N628) &TGF-b1 (L30-S390) ) produced by HEK293 cells with His tag[1][2].

Product Specifications

Product Name Alternative

GARP&Latent TGF beta Complex Protein, Mouse (HEK293, His), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/garp-latent-tgf-beta-complex-protein-mouse-hek293-his.html

Purity

95.00

Molecular Formula

434215&21803 (Gene_ID) G3XA59 (A18-L628) &P04202 (L30-S390) (Accession)

Molecular Weight

70-80 kDa

References & Citations

[1]Soyoung A Oh, TGF-β: guardian of T cell function. J Immunol. 2013 Oct 15;191 (8) :3973-9.|[2]Angela X Zhou, et al. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol. 2013 May 15;190 (10) :5057-64.|[3]Justin P Edwards, et al. The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance. Eur J Immunol. 2016 Jun;46 (6) :1480-9.|[4]Dulce Maroni, et al. TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum. Cell Sci. 2011 Jul 15;124 (Pt 14) :2501-10.|[5]Justin Rustenhoven, et al. TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function. Justin Rustenhoven. 2016 Feb 11;13:37.|[6]Kai Zhang, et al. Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R) -ketamine and the novel antidepressant TGF-β1. Transl Psychiatry. 2020 Jan 27;10 (1) :32.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Storage Conditions

Stored at -20°C for 2 years

Scientific Category

Recombinant Proteins

Available Sizes

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