Lck (phospho Tyr505) rabbit pAb
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016],
Product Specifications
Background
Synonyms
Gene ID
3932
UniProt
P06239
Cellular Locus
Cell membrane ; Lipid-anchor ; Cytoplasmic side. Cytoplasm, cytosol. Present in lipid rafts in an inactive form..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Lck around the phosphorylation site of Tyr505. AA range:460-509
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
56kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES6095-1.pdf
Observed Molecular Weight
56 kD
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytosol . Present in lipid rafts in an inactive form. .
Other Product Names
Gene ID (Human)
3932
SwissProt (Human)
P06239
Available Sizes
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