Tolrestat

Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.

Product Specifications

CAS Number

[82964-04-3]

Product Name Alternative

AY-27773

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aldose Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tolrestat.html

Purity

99.37

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CN(C(C1=C2C=CC(OC)=C(C(F)(F)F)C2=CC=C1)=S)C

Molecular Formula

C16H14F3NO3S

Molecular Weight

357.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Sestanj K, et al. N-[5- (trifluoromethyl) -6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27 (3) :255-6.|[2]Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34 (10) :885-92.|[3]Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105 (8) :793-802.