Tolrestat
Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
Product Specifications
CAS Number
[82964-04-3]
Product Name Alternative
AY-27773
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tolrestat.html
Purity
99.37
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CN(C(C1=C2C=CC(OC)=C(C(F)(F)F)C2=CC=C1)=S)C
Molecular Formula
C16H14F3NO3S
Molecular Weight
357.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Sestanj K, et al. N-[5- (trifluoromethyl) -6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27 (3) :255-6.|[2]Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34 (10) :885-92.|[3]Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105 (8) :793-802.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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