KCNQ2/3/4/5 rabbit pAb
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
O43526/O43525/P56696/Q9NR82
Swiss Prot
O43526/O43525/P56696/Q9NR82
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3. AA range:191-240
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein .
Other Product Names
Gene ID (Human)
3786
Available Sizes
Frequently Asked Questions
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