4-Oxofenretinide-d4
Product Specifications
UNSPSC Description
4-Oxofenretinide-d4 (4-Oxo-4-HPR-d4) is deuterium labeled 4-Oxofenretinide. 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1][2].
Target Antigen
Apoptosis; Drug Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Others
Field of Research
Cancer
Smiles
CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(NC2=C([2H])C([2H])=C(O)C([2H])=C2[2H])=O
Molecular Weight
409.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.|[3]Villani
MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,
induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive
and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
2991099-34-2
Curated Selection
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