14-3-3 σ rabbit pAb
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. function: p53-regulated inhibitor of G2/M progression. similarity: Belongs to the 14-3-3 family. subcellular location: May be secreted by a non-classical secretory pathway. subunit: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. tissue specificity: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
Product Specifications
Background
Synonyms
SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin
Gene ID
2810
UniProt
P31947
Cellular Locus
Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
30kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES5572-1.pdf
Observed Molecular Weight
30 kD
Subcellular Location
Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.
Other Product Names
SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin
Gene ID (Human)
2810
SwissProt (Human)
P31947
Available Sizes
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