LAT (phospho Tyr191) rabbit pAb
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
O43561
Swiss Prot
O43561
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human LAT around the phosphorylation site of Tyr191. AA range:191-240
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
28kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
28kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.
Other Product Names
LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38
Gene ID (Human)
27040
Available Sizes
Frequently Asked Questions
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