HBP1 (phospho Ser402) rabbit pAb
Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. similarity: Contains 1 AXH domain. similarity: Contains 1 HMG box DNA-binding domain. subunit: Binds the second PAH repeat of SIN3A (By similarity). Binds TCF4 and RB1.
Product Specifications
Background
Synonyms
HBP1; HMG box-containing protein 1; HMG box transcription factor 1; High mobility group box transcription factor 1
Gene ID
26959
UniProt
O60381
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human HBP1 around the phosphorylation site of Ser402. AA range:371-420
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
58kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES5519-1.pdf
Observed Molecular Weight
58 kD
Subcellular Location
Nucleus .
Other Product Names
HBP1; HMG box-containing protein 1; HMG box transcription factor 1; High mobility group box transcription factor 1
Gene ID (Human)
26959
SwissProt (Human)
O60381
Available Sizes
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