P52 S6 kinase rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Caution: Instead of Lys-820, Arg-820 is found at the binding site. Domain: The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site. function: May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily. similarity: Contains 1 MIT domain. similarity: Contains 1 PX (phox homology) domain. similarity: Contains 2 protein kinase domains. subcellular location: Also found in some small dot-like or ring-shaped early endosome structures. subunit: Interacts with SPHK1 and phosphatidylinositol 3-phosphate. tissue specificity: Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.