TIN2 rabbit pAb
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010],
Product Specifications
Background
Synonyms
TINF2; TIN2; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Gene ID
26277
UniProt
Q9BSI4
Cellular Locus
Nucleus. Chromosome, telomere. Associated with telomeres.; [Isoform 1]: Nucleus matrix.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TINF2. AA range:71-120
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
53kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES5486-1.pdf
Observed Molecular Weight
53 kD
Subcellular Location
Nucleus . Chromosome, telomere . Associated with telomeres.; [Isoform 1]: Nucleus matrix .
Other Product Names
TINF2; TIN2; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
Gene ID (Human)
26277
SwissProt (Human)
Q9BSI4
Available Sizes
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