Nkx-2.8 rabbit pAb
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015],
Product Specifications
Background
UniProt
Q8IUT7
Swiss Prot
Q8IUT7
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human NKX28. AA range:20-69
Target
Nkx-2.8
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
26kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
26kD
Fragment
IgG
Subcellular Location
Nucleus
Gene ID (Human)
26257
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
