Sck rabbit pAb

Domain: The PID domain mediates binding to the TrkA receptor. function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. miscellaneous: PubMed: 15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed: 12006576. PTM: Phosphorylated on tyrosines by the Trk receptors. similarity: Contains 1 PID domain. similarity: Contains 1 SH2 domain. subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Product Specifications

Background

Domain:The PID domain mediates binding to the TrkA receptor., function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons., miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576., PTM:Phosphorylated on tyrosines by the Trk receptors., similarity:Contains 1 PID domain., similarity:Contains 1 SH2 domain., subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2., tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Product Name Alternative

SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2

UniProt

P98077

Swiss Prot

P98077

Reactivity

Human; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310

Target

Sck

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Buffer

-20°C/1 year

Molecular Weight

59kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

59kD

Fragment

IgG

Subcellular Location

Intracellular, cytosol, plasma membrane

Other Product Names

SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2