Sanguinarine (chloride)

Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS) . Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

Product Specifications

CAS Number

[5578-73-4]

Product Name Alternative

Sanguinarin (chloride) ; Sanguinarium (chloride) ; Pseudochelerythrine (chloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Bacterial; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Sanguinarine-chloride.html

Purity

98.93

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

C[N+]1=CC2=C3C(OCO3)=CC=C2C(C=CC4=C5)=C1C4=CC6=C5OCO6.[Cl-]

Molecular Formula

C20H14ClNO4

Molecular Weight

367.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang Y, Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016 Apr 19;7 (16) :22355-67.