SIRT1 (phospho Ser47) rabbit pAb
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],
Product Specifications
Background
UniProt
Q96EB6
Swiss Prot
Q96EB6
Reactivity
Human; Mouse
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human SIRT1 (phospho Ser47)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Molecular Weight
85-110kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85-110kD
Fragment
IgG
Subcellular Location
Other Product Names
SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2
Gene ID (Human)
23411
Available Sizes
Frequently Asked Questions
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