JMJD2B rabbit pAb
Cofactor: Binds 1 Fe (2+) ion per subunit. Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. similarity: Belongs to the JHDM3 histone demethylase family. similarity: Contains 1 JmjC domain. similarity: Contains 1 JmjN domain. similarity: Contains 2 PHD-type zinc fingers. similarity: Contains 2 Tudor domains.
Product Specifications
Background
Synonyms
Gene ID
23030
UniProt
O94953
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human KDM4B. AA range:351-400
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, ELISA
Validated Applications
IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES5294-1.pdf
Subcellular Location
Nucleus .
Other Product Names
Gene ID (Human)
23030
SwissProt (Human)
O94953
Available Sizes
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