Palladin rabbit pAb

This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Product Specifications

Background

UniProt

Q8WX93

Swiss Prot

Q8WX93

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from Palladin . at AA range: 450-530

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

150kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

150kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, ruffle . Cell projection, podosome . Cell projection, lamellipodium . Cell projection, axon . Cell projection, growth cone . Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434) . Preferentially expressed in the excitatory presynaptic terminals (By similarity) . .