TPX2 rabbit pAb

Developmental stage: Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. subcellular location: During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. tissue specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues.

Product Specifications

Background

Developmental stage:Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., subcellular location:During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus., tissue specificity:Expressed in lung carcinoma cell lines but not in normal lung tissues.

Product Name Alternative

TPX2; C20orf1; C20orf2; DIL2; HCA519; Targeting protein for Xklp2; Differentially expressed in cancerous and non-cancerous lung cells 2; DIL-2; Hepatocellular carcinoma-associated antigen 519; Protein fls353; Restricted expression prolifera

UniProt

Q9ULW0

Swiss Prot

Q9ULW0

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human DIL-2. AA range:301-350

Target

TPX2

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

86kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

86kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. .