Tc-Me2P

Tc-Me2P is a 99MTC-labeled acrylamide (PnAO) derivative that contains two 4-methyl-2-nitroimidazole groups. The primary activity of Tc-Me2P is as an imaging agent for tumor hypoxia. By specifically binding to hypoxic regions in tumor tissue, it can be used for single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging to detect hypoxia in tumors. Tc-Me2P can be used to study the targeting of different chemical structures in tumors and normal tissues[1].

Product Specifications

UNSPSC

12352005

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tc-me2p.html

Smiles

O=[Tc]123N4CCCN1C(C)(C)C(CN5C=C(C)N=C5[N+]([O-])=O)=[N]2O[H]O[N]3=C(CN6C=C(C)N=C6[N+]([O-])=O)C4(C)C

Molecular Formula

C21H31N10O7Tc

Molecular Weight

634.44

References & Citations

[1]Li S, et al. Preparation and bioevaluation of a novel 99mTc-labelled propylene amine oxime (PnAO) containing two 4-methyl-2-nitroimidazole groups as a promising tumor hypoxia imaging agent[J]. Bioorganic & Medicinal Chemistry Letters, 2024, 106: 129773.