ZNRF2 rabbit pAb

Domain: The RING-type zinc finger domain is required for E3 ligase activity. function: May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. pathway: Protein modification; protein ubiquitination. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 RING-type zinc finger. subcellular location: Present in presynaptic plasma membranes in neurons. subunit: Interacts with UBE2N. tissue specificity: Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.