FoxK1 rabbit pAb

Function: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli. PTM: Phosphorylated. similarity: Contains 1 FHA domain. similarity: Contains 1 fork-head DNA-binding domain. subunit: Interacts with SIN3B to form a complex which represses transcription. tissue specificity: Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.

Product Specifications

Background

Function:Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli., PTM:Phosphorylated., similarity:Contains 1 FHA domain., similarity:Contains 1 fork-head DNA-binding domain., subunit:Interacts with SIN3B to form a complex which represses transcription., tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.

UniProt

P85037

Swiss Prot

P85037

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human FOXK1. AA range:681-730

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

78kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

78kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity) . Accumulates in the nucleus upon viral infection (PubMed:25852164) . .