TD-0212 (TFA)
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
Product Specifications
CAS Number
1073549-11-7
Product Name Alternative
8-Nitrotryptanthrin
UNSPSC
12352005
Target
Angiotensin Receptor; Neprilysin
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/td-0212-tfa.html
Concentration
10mM
Purity
98.44
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.OC(C1=CC=CC=C1C2=CC=C(CN3C(CNC([C@H](CC(C)C)S)=O)=C(CC)N=C3OCC)C(F)=C2)=O
Molecular Formula
C30H35F4N3O6S
Molecular Weight
641.67
References & Citations
[1]McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI) . ACS Med Chem Lett. 2018 Dec 3;10 (1) :86-91.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor
Available Sizes
Frequently Asked Questions
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