TD-0212 (TFA)
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
Product Specifications
CAS Number
1073549-11-7
Product Name Alternative
8-Nitrotryptanthrin
UNSPSC
12352005
Target
Angiotensin Receptor; Neprilysin
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/td-0212-tfa.html
Concentration
10mM
Purity
98.44
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.OC(C1=CC=CC=C1C2=CC=C(CN3C(CNC([C@H](CC(C)C)S)=O)=C(CC)N=C3OCC)C(F)=C2)=O
Molecular Formula
C30H35F4N3O6S
Molecular Weight
641.67
References & Citations
[1]McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI) . ACS Med Chem Lett. 2018 Dec 3;10 (1) :86-91.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![PSMB9 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3H1]](https://cdn.genprice.uk/products/937/68dd1b6d061270361ea17330/imageurl/ta504388bm.webp)
TA504388BM 100 µL
PSMB9 Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3H1]
Sign In for Pricing
View Details 
E-EL-MK1612-01 24 Tests
Monkey C5a (Complement Component 5a) ELISA Kit
Sign In for Pricing
View Details